University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Analysis of long-range contacts across cell types outlines a core sequence determinant of 3D genome organisation
L Tamon, Z Fahmi, J Ashford, R Collepardo-Guevara, AB Sahakyan
(2025)
Molecular insights on the mechanism of α1-antitrypsin condensate formation and maturation
I Sanchez-Burgos, AR Tejedor, R Collepardo-Guevara, JB de la Serna, JR Espinosa
(2025)
Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells
MA Shimazoe, J Huertas, C Phillips, S Ide, S Tamura, S Farr, SS Ashwin, M Sasai, R Collepardo-Guevara, K Maeshima
(2025)
Compositional control of ageing kinetics in TDP-43 condensates
NH Espejo, A Feito, I Sanchez-Burgos, A Garaizar, MM Conde, A Rey, A Castro, R Collepardo-Guevara, AR Tejedor, JR Espinosa
(2025)
Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC
M Montez, D Zhu, JH Martin, MJ Maristany, B Rutjens, M Nielsen, R Collepardo-Guevara, C Dean
(2025)
Decoding phase separation of prion-like domains through data-driven scaling laws.
MJ Maristany, AA Gonzalez, JR Espinosa, J Huertas, R Collepardo-Guevara, JA Joseph
Elife
(2025)
13
Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates.
A R Tejedor, A Aguirre Gonzalez, MJ Maristany, PY Chew, K Russell, J Ramirez, JR Espinosa, R Collepardo-Guevara
ACS central science
(2025)
11
Benchmarking residue-resolution protein coarse-grained models for simulations of biomolecular condensates.
A Feito, I Sanchez-Burgos, I Tejero, E Sanz, A Rey, R Collepardo-Guevara, AR Tejedor, JR Espinosa
PLoS Comput Biol
(2025)
21
Decoding Phase Separation of Prion-Like Domains through Data-Driven Scaling Laws
MJ Maristany, A Aguirre Gonzalez, JR Espinosa, J Huertas, R Collepardo-Guevara, JA Joseph
(2025)
Nucleosome Spacing Can Fine-Tune Higher Order Chromatin Assembly
L Chen, MJ Maristany, SE Farr, J Luo, BA Gibson, LK Doolittle, JR Espinosa, J Huertas, S Redding, R Collepardo-Guevara, MK Rosen
(2024)

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Click on an image to view animations from Energy Landscapes of Model Knotted Polymers, Journal of Chemical Theory and Computation, Tongfan Hao, Yinghao Ge, Mark A. Miller, Agustin L. N. Francesco, David J. Wales, DOI 10.1021/acs.jctc.5c01005

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