University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Designing multiphase biomolecular condensates by coevolution of protein mixtures
(2022)
(doi: 10.1101/2022.04.22.489187)
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
(2022)
2022.03.30.486367
(doi: 10.1101/2022.03.30.486367)
Multiscale modelling of chromatin organisation: Resolving nucleosomes at near-atomistic resolution inside genes
Curr Opin Cell Biol
(2022)
75
102067
(doi: 10.1016/j.ceb.2022.02.001)
Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates.
Sci Rep
(2022)
12
4390
(doi: 10.1038/s41598-022-08130-2)
RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins.
PLOS Computational Biology
(2022)
18
e1009810
(doi: 10.1371/journal.pcbi.1009810)
Physics-driven coarse-grained model for biomolecular phase separation with near-quantitative accuracy
Biophysical Journal
(2022)
121
307A
(doi: 10.1016/j.bpj.2021.11.1214)
Comparison of experimental phase diagrams and residue-level coarse-grained simulations of intrinsically disordered proteins
Biophysical Journal
(2022)
121
471A
(doi: 10.1016/j.bpj.2021.11.408)
Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates.
Nano Letters: a journal dedicated to nanoscience and nanotechnology
(2022)
22
612
(doi: 10.1021/acs.nanolett.1c03138)
Study on stability, composition, and protein arrangement within bio-condensates formed via liquid-liquid phase separation
BIOPHYSICAL JOURNAL
(2022)
121
357A
Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides.
Journal of the American Chemical Society
(2021)
144
368
(doi: 10.1021/jacs.1c10241)
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