University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
Nat Commun
(2021)
12
1085
(doi: 10.1038/s41467-021-21181-9)
Valency and binding affinity variations can regulate the multilayered organization of protein condensates with many components
Biomolecules
(2021)
11
278
(doi: 10.3390/biom11020278)
Thermodynamics and kinetics of phase separation of protein-RNA mixtures by a minimal model
Biophysical Journal
(2021)
120
1219
(doi: 10.1016/j.bpj.2021.01.031)
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
(2020)
(doi: 10.1101/2020.11.23.391599)
Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence
(2020)
(doi: 10.1101/2020.10.20.347542)
Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid-Liquid Phase Separation
Molecules
(2020)
25
E4705
(doi: 10.3390/molecules25204705)
DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions
Nucleic Acids Research
(2020)
48
gkaa466-
(doi: 10.1093/nar/gkaa466)
Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components.
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
13238
(doi: 10.1073/pnas.1917569117)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
BIOPHYSICAL JOURNAL
(2020)
120
28A
(doi: 10.1101/2020.05.04.076299)
Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1
Nucleic Acids Research
(2020)
48
5318
(doi: 10.1093/NAR/GKAA285)
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