University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions
Nucleic Acids Research
(2020)
48
7333
(doi: 10.1093/nar/gkaa466)
Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components
Proc Natl Acad Sci U S A
(2020)
117
13238
(doi: 10.1073/pnas.1917569117)
Reentrant Liquid Condensate Phase of Proteins is Stabilized by Hydrophobic and Non-Ionic interactions
BIOPHYSICAL JOURNAL
(2020)
120
28A
(doi: 10.1101/2020.05.04.076299)
Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1
Nucleic Acids Research
(2020)
48
5318
(doi: 10.1093/NAR/GKAA285)
Surface electrostatics govern the emulsion stability of biomolecular condensates
(2020)
2020.04.20.047910
(doi: 10.1101/2020.04.20.047910)
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
7216
(doi: 10.1073/pnas.1910044117)
Oligonucleotides can act as superscaffolds that enhance liquid-liquid phase separation of intracellular mixtures
(2020)
2020.01.24.916858
(doi: 10.1101/2020.01.24.916858)
Phosphorylation of Intrinsically Disordered Regions within the Genome
BIOPHYSICAL JOURNAL
(2020)
118
296A
Breakdown of the law of rectilinear diameter and related surprises in the liquid-vapor coexistence in systems of patchy particles.
J Chem Phys
(2019)
150
224510
(doi: 10.1063/1.5098551)
Chromatin Structure Regulation by an Epigenetic Switch Tuning the Flexibility of the H1 C-Terminal Domain
Biophysical Journal
(2019)
116
70a
(doi: 10.1016/j.bpj.2018.11.420)
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