University Associate Professor
Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation.
Professor Collepardo discusses her research
Publications
Chromatin unfolding by epigenetic modifications explained by dramatic impairment of internucleosome interactions: A multiscale computational study
J Am Chem Soc
(2015)
137
10205
(doi: 10.1021/jacs.5b04086)
Forced unraveling of chromatin fibers with nonuniform linker DNA lengths
Journal of Physics: Condensed Matter
(2015)
27
064113
Energy Landscapes, Folding Mechanisms, and Kinetics of RNA Tetra loop Hairpins
J Am Chem Soc
(2014)
136
18052
(doi: 10.1021/ja5100756)
Structure and Properties of DNA in Apolar Solvents
The journal of physical chemistry. B
(2014)
118
8540
(doi: 10.1021/jp503816r)
Dynamic condensation of linker histone C-terminal domain regulates chromatin structure
Nucleic Acids Research
(2014)
42
7553
(doi: 10.1093/nar/gku491)
Chromatin fiber polymorphism triggered by variations of DNA linker lengths.
Proceedings of the National Academy of Sciences of the United States of America
(2014)
111
8061
(doi: 10.1073/pnas.1315872111)
NAFlex: a web server for the study of nucleic acid flexibility.
Nucleic acids research
(2013)
41
w47
(doi: 10.1093/nar/gkt378)
Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments
Biochemical Society Transactions
(2013)
41
494
(doi: 10.1042/BST20120349)
Insights into chromatin architecture by mesoscale modeling of oligonucleosomes
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
246
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes.
Nucleic Acids Res
(2012)
40
8803
(doi: 10.1093/nar/gks600)
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