University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Surface electrostatics govern the emulsion stability of biomolecular condensates
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
(2020)
Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry
A Sridhar, SE Farr, G Portella, T Schlick, M Orozco, R Collepardo-Guevara
Proceedings of the National Academy of Sciences of the United States of America
(2020)
117
Oligonucleotides can act as superscaffolds that enhance liquid-liquid phase separation of intracellular mixtures
JA Joseph, JR Espinosa, I Sanchez-Burgos, A Garaizar, D Frenkel, R Collepardo-Guevara
(2020)
Phosphorylation of Intrinsically Disordered Regions within the Genome
A Sridhar, G Portella, M Orozco, R Collepardo-Guevara
BIOPHYSICAL JOURNAL
(2020)
118
Breakdown of the law of rectilinear diameter and related surprises in the liquid-vapor coexistence in systems of patchy particles
JR Espinosa, A Garaizar, C Vega, D Frenkel, R Collepardo-Guevara
The Journal of Chemical Physics
(2019)
150
Chromatin Structure Regulation by an Epigenetic Switch Tuning the Flexibility of the H1 C-Terminal Domain
A Sridhar, S Farr, G Portella, T Schlick, M Orozco, R Collepardo-Guevara
Biophysical Journal
(2019)
116
Chromatin unfolding by epigenetic modifications explained by dramatic impairment of internucleosome interactions: A multiscale computational study
R Collepardo-Guevara, G Portella, M Vendruscolo, D Frenkel, T Schlick, M Orozco
Journal of the American Chemical Society
(2015)
137
Forced unraveling of chromatin fibers with nonuniform linker DNA lengths.
G Ozer, R Collepardo-Guevara, T Schlick
Journal of Physics: Condensed Matter
(2015)
27
Energy Landscapes, Folding Mechanisms, and Kinetics of RNA Tetra loop Hairpins
D Chakraborty, R Collepardo-Guevara, DJ Wales
J Am Chem Soc
(2014)
136
Structure and Properties of DNA in Apolar Solvents
A Arcella, G Portella, R Collepardo-Guevara, D Chakraborty, DJ Wales, M Orozco
J Phys Chem B
(2014)
118

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Click on an image to view animations from Energy Landscapes of Model Knotted Polymers, Journal of Chemical Theory and Computation, Tongfan Hao, Yinghao Ge, Mark A. Miller, Agustin L. N. Francesco, David J. Wales, DOI 10.1021/acs.jctc.5c01005

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