University Associate Professor

Rosana is the Professor of Computational and Molecular Biophysics at the Departments of Chemistry and Genetics, and a Winton Advanced Research Fellow in the Department of Physics. Her group develops multiscale modelling approaches to investigate the physicochemical driving forces that govern DNA packaging inside cells, membraneless compartamentalization via liquid-liquid phase behaviour of biomolecules (proteins, nucleic acids, and chromatin), chromatin structure, epigenetic phenomena, and the relationship between the structure of the genome and gene expression regulation. 

Professor Collepardo discusses her research

Publications

Dynamic condensation of linker histone C-terminal domain regulates chromatin structure.
A Luque, R Collepardo-Guevara, S Grigoryev, T Schlick
Nucleic Acids Research
(2014)
42
Chromatin fiber polymorphism triggered by variations of DNA linker lengths.
R Collepardo-Guevara, T Schlick
Proceedings of the National Academy of Sciences
(2014)
111
NAFlex: a web server for the study of nucleic acid flexibility
A Hospital, I Faustino, R Collepardo-Guevara, C González, JL Gelpí, M Orozco
Nucleic acids research
(2013)
41
Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments.
R Collepardo-Guevara, T Schlick
Biochemical Society Transactions
(2013)
41
Insights into chromatin architecture by mesoscale modeling of oligonucleosomes
AL Santolaria, R Collepardo-Guevara, S Grigoryev, T Schlick
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
246
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes.
R Collepardo-Guevara, T Schlick
Nucleic Acids Research
(2012)
40
The effect of linker histone's nucleosome binding affinity on chromatin unfolding mechanisms.
R Collepardo-Guevara, T Schlick
Biophysical Journal
(2011)
101
Bimolecular reaction rates from ring polymer molecular dynamics: Application to H+CH4 → H2+CH3
YV Suleimanov, R Collepardo-Guevara, DE Manolopoulos
Journal of Chemical Physics
(2011)
134
Biomolecular modeling and simulation: a field coming of age
T Schlick, R Collepardo-Guevara, LA Halvorsen, S Jung, X Xiao
Quarterly reviews of biophysics
(2011)
44
Modeling Studies of Chromatin Fiber Structure as a Function of DNA Linker Length
O Perišić, R Collepardo-Guevara, T Schlick
Journal of Molecular Biology
(2010)
403

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